A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir

L Dalla-Vechia, B Reichart, T Glasnov…

文献索引：Organic and Biomolecular Chemistry, , vol. 11, # 39 p. 6806 - 6813

全文：HTML全文

被引用次数: 19

摘要

... ranked continuous flow processing as a high priority research area for pharmaceutical and fine chemical manufacturing. ... 1,2 A particularly challenging area in flow chemistry is to perform multi-step reaction sequences ... 5, and Pd(PPh 3 ) 4 as a catalyst in 2.3 mL of organic solvent ...