Tetrahedron

Synthesis and applications of chiral bis-THF in asymmetric synthesis

A Alexakis, A Tomassini, S Leconte

文献索引：Alexakis, Alexandre; Tomassini, Axel; Leconte, Stephane Tetrahedron, 2004 ,  vol. 60,  # 42  p. 9479 - 9484

全文：HTML全文

被引用次数: 18

摘要

The synthesis of enantiopure bis-THF is described, starting from d-mannitol. Bis-THF is used as chiral ligand for organolithium reagents in four different reactions. The enantioselectivity provided by this ligand is moderate, and the asymmetric induction is in line with the expected model.