Tetrahedron

Syntheses of nucleic acid mimics designed for metal-induced strand formation on DNA

A Hatano, K Tanaka, M Shiro, M Shionoya

文献索引：Hatano, Akihiko; Tanaka, Kentaro; Shiro, Motoo; Shionoya, Mitsuhiko Tetrahedron, 2002 , vol. 58, # 15 p. 2965 - 2972

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被引用次数: 8

摘要

This paper describes design and syntheses of a new class of chelator-type nucleic acid mimics. Four nucleic acid mimics 7, 11, 15, 17 possess a nucleobase and two ethylenediamine moieties for intermolecular metal coordination. We expected that chelator- type nucleic acid mimics formed a strand in the presence of metal ion and then interacted with a single-stranded DNA. Efficient synthetic routes leading to the four nucleic acid ...