DL-Tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy
WHW Lunn, DD Schoepp, DO Calligaro…
文献索引：Lunn, W. H. W.; Schoepp, Darryle D.; Calligaro, David O.; Vasileff, R. T.; Heinz, L. J.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 24 p. 4608 - 4612
acid (8) by heating with NaN3 in DMF for 30 h at 70" C. Hydrolysis of the ester was accomplished with aqueous NaOH at room temperature for 3 h. However, the resulting Na salt was extremely insoluble and heating with excess aqueous HC1 was required to obtain the oxime free acid (9). This acid was then hydrogenated to the desired amino acid 5 in HzO using PtO2 as the catalyst. The product crystallized out from the hydrogenation mixture, ...
