The parallel synthesis of small focused libraries has become an important strategy for the follow-up of screening hits. The benzoxazole scaffold 1 is found in many biologically active compounds, such as elastase inhibitors 1 and H 2 -antagonists. 2 There are several reports 3., , and for the synthesis of benzoxazoles including one which uses solid-phase support. 4 Although the latter method does allow the parallel synthesis of libraries, product diversity is limited ...
