Cyclic urea derivatives as potent NK 1 selective antagonists

…, JH Schwerdt, S Shah, GA Reichard, JJ Piwinski…

文献索引：Shue, Ho-Jane; Chen, Xiao; Shih, Neng-Yang; Blythin, David J.; Paliwal, Sunil; Lin, Ling; Gu, Danlin; Schwerdt, John H.; Shah, Sapna; Reichard, Gregory A.; Piwinski, John J.; Duffy, Ruth A.; Lachowicz, Jean E.; Coffin, Vicki L.; Liu, Fei; Nomeir, Amin A.; Morgan, Cynthia A.; Varty, Geoffrey B. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3896 - 3899

全文：HTML全文

被引用次数: 45

摘要

A series of novel five-and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.