Abstract Purpose. A series of derivatives having a propranolol-like moiety linked to NO- donor furoxan substructures were synthesized. The main objective of this investigation was to obtain agents with mixed NO-dependent vasodilating and β-blocking activities. Methods. Most of the target compounds were synthesized from the appropriate furoxans bearing XCH 2 CH 2 NH 2 (X= O, S, SO 2) chains at the 4 position of the ring, using A1 (C 2 H 5) 3 in ...
