A modular approach for the construction and modification of glyco-SAMs utilizing 1, 3-dipolar cycloaddition

…, T Winkler, A Terfort, TK Lindhorst

文献索引：Kleinert, Mike; Winkler, Tobias; Terfort, Andreas; Lindhorst, Thisbe K. Organic and Biomolecular Chemistry, 2008 , vol. 6, # 12 p. 2118 - 2132

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被引用次数: 51

摘要

We report the synthesis of a broad variety of functionalized molecules for assembly on gold, allowing the formation of biologically relevant SAMs by a modular approach: either utilizing 1, 3-dipolar cycloaddition of alkynes and azides in solution or by 'click on SAM'. Extensive studies into the various parameters of SAM formation and stability have been carried out, leading us to deduce reliable conditions under which glyco-decorated self-assembled ...