Synthesis and biological activity of N-arylamidines of nicotinic and 2-methoxy-6-methylnicotinic acids and their derivatives
VA Khaldeeva, NI Shramm, NA Podushkina…
文献索引：Khaldeeva, V. A.; Shramm, N. I.; Podushkina, N. A.; Zalesov, V. S.; Mikhalev, A. I.; Konshin, M. E. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 2 p. 93 - 95 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 2 p. 148 - 151
In [2, 3] it was shown that hydrazides and amides of oxalic acid have different types of biological activity. It was therefore interesting to introduce the ethoxalyl and oxamoyl radicals into the molecule of amidines II-V. It was found that with short boiling of the alcoholic solutions of compounds II-V with diethyl oxalate, they are converted into N-aryl-N1- ethoxalylamidines of 2-methoxy-6-methylnicotinic acid (X-XIII). It was shown in the case of ...
