Reductions with lithium in low molecular weight amines and ethylenediamine

…, NA Fedoruk, NC Chamberlain, AA Avey

文献索引：Garst; Dolby; Esfandiari; Fedoruk; Chamberlain; Avey Journal of Organic Chemistry, 2000 , vol. 65, # 21 p. 7098 - 7104

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被引用次数: 20

摘要

Reductions of several types of compounds with lithium and ethylenediamine using low molecular weight amines as solvent are described. In all cases 1 mol of ethylenediamine or N, N'-dimethylethylenediamine per gram-atom of lithium was used. In some cases it was beneficial to add an alcohol as a proton donor. These reaction conditions were applied to the debenzylation of N-benzylamide and lactams which are refractory to hydrogenolysis ...