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The Journal of organic chemistry

A convenient new synthesis of benzo [a] pyrene

RG Harvey, K Lim, Q Dai

文献索引:Harvey, Ronald G.; Lim, Keunpoong; Dai, Qing Journal of Organic Chemistry, 2004 , vol. 69, # 4 p. 1372 - 1373

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被引用次数: 9

摘要

A convenient new synthesis of the ubiquitous environmental carcinogen benzo [a] pyrene (BaP) is described. In the key step, the method entails Suzuki coupling of naphthalene 2- boronic acid with 2-bromobenzene-1, 3-dialdehyde and requires only three steps. It is considerably shorter and simpler than the older methods and provides BaP in higher overall yield.