Toll-like receptor 2 antagonists. Part 1: preliminary SAR investigation of novel synthetic phospholipids

MR Spyvee, H Zhang, LD Hawkins, JC Chow

文献索引：Spyvee, Mark R.; Zhang, Huiming; Hawkins, Lynn D.; Chow, Jesse C. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 24 p. 5494 - 5498

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被引用次数: 19

摘要

Novel synthetic phospholipid compound 1 was discovered to be an antagonist of human toll- like receptor 2 (TLR2) signaling. In a preliminary SAR campaign we synthesized several analogues of 1 and found that considerable structural changes could be made without loss of TLR2 antagonistic activity.