New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties

…, DR Sawicki, L Seestaller, D Sullivan…

文献索引：Malamas, Michael S.; Sredy, Janet; Gunawan, Iwan; Mihan, Brenda; Sawicki, Diane R.; Seestaller, Laura; Sullivan, Donald; Flam, Brenda R. Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 995 - 1010

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被引用次数: 132

摘要

Insulin resistance in the liver and peripheral tissues together with a pancreatic cell defect are the common causes of type 2 diabetes. It is now appreciated that insulin resistance can result from a defect in the insulin receptor signaling system, at a site post binding of insulin to its receptor. Protein tyrosine phosphatases (PTPases) have been shown to be negative regulators of the insulin receptor. Inhibiton of PTPases may be an effective method in the ...