Synthesis of the enantiomers of the dual function 2??nitroimidazole radiation sensitizer RB 6145
…, ME Marlatt, B Leja, HD Showalter…
文献索引：Sercel, Anthony D.; Beylin, Vladimir G.; Marlatt, Mark E.; Leja, Boguslawa; Showalter, H. D. Hollis; Michel, Andre Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1597 - 1604
Radiation sensitizers represent an enticing concept in tumour therapy. The objective of directed radiation along with a co-administrated sensitizing agent is to achieve a maximum effect on tumour tissue, while minimizing the damage to normal tissues. Many tumours are characterized by a lower oxygen pressure relative to normal tissue, resulting in the formation of clusters of hypoxic cells in response to reduced oxygen diffusion. These hypoxic cells ...
