A labeled guanidine ligand for studying sweet taste

…, K Burgess, D Pledger, N Cairns, DS Linthicum

文献索引：Feng, Yangbo; Burgess, Kevin; Pledger, David; Cairns, Nick; Linthicum, D. Scott Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 881 - 884

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被引用次数: 8

摘要

A synthesis of a biotinylated-, coumarin-substituted-N, N'-diarylguanidine 1 is reported. This ligand has structural features conducive to studying sweet taste including a fluorescent tag to facilitate spectroscopic studies of binding to protein-receptors for sweet ligands and an anchor for affinity purification.