Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity
D Renck, P Machado, AA Souto…
文献索引：Hirohashi; Kido; Yamamoto; Kojima; Jitsukawa; Fujii Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 9 p. 1498 - 1506
... Volume: Page: ... Design and Chemistry First, in our strategy to obtain novel compounds with hUP1 inhibitory activity, we maintained the 2,6-dihydroxyl ... To evaluate the effect of chemical substitutions at different positions, a series of 6-hydroxy-1H-pyridin-2-one-3 ...
