Cell Division Cycle 7 Kinase Inhibitors: 1 H-Pyrrolo [2, 3-b] pyridines, Synthesis and Structure− Activity Relationships

…, A Isacchi, M Menichincheri, A Molinari…

文献索引：Ermoli, Antonella; Bargiotti, Alberto; Brasca, Maria Gabriella; Ciavolella, Antonella; Colombo, Nicoletta; Fachin, Gabriele; Isacchi, Antonella; Menichincheri, Maria; Molinari, Antonio; Montagnoli, Alessia; Pillan, Antonio; Rainoldi, Sonia; Sirtori, Federico Riccardi; Sola, Francesco; Thieffine, Sandrine; Tibolla, Marcellino; Valsasina, Barbara; Volpi, Daniele; Santocanale, Corrado; Vanotti, Ermes Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4380 - 4390

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被引用次数: 40

摘要

Cdc7 kinase has recently emerged as an attractive target for cancer therapy and low- molecular-weight inhibitors of Cdc7 kinase have been found to be effective in the inhibition of tumor growth in animal models. In this paper, we describe synthesis and structure− activity relationships of new 1 H-pyrrolo [2, 3-b] pyridine derivatives identified as inhibitors of Cdc7 kinase. Progress from (Z)-2-phenyl-5-(1 H-pyrrolo [2, 3-b] pyridin-3-ylmethylene)-3, 5- ...