Novel ketolide antibiotics with a fused five-membered lactone ring––synthesis, physicochemical and antimicrobial properties

…, W Arnold, A Stämpfli, A Schmitt-Hoffmann…

文献索引：Hunziker, Daniel; Wyss, Pierre-C.; Angehrn, Peter; Mueller, Aranka; Marty, Hans-Peter; Halm, Remy; Kellenberger, Laurenz; Bitsch, Veronique; Biringer, Gerard; Arnold, Wolf; Staempfli, Andreas; Schmitt-Hoffmann, Anne; Cousot, Denis Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 13 p. 3503 - 3519

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被引用次数: 28

摘要

In an effort to find novel semisynthetic macrolides with extended antibacterial spectrum and improved activity we prepared a series of compounds based on commercially available clarithromycin, a potent and safe antimicrobial agent of outstanding clinical and commercial interest. According to the literature, improvement of antibacterial activity of erythromycin type antibiotics can be achieved by introduction of fused heterocycles such as cyclic ...