Drug Metabolism and Disposition

Metabolism of methylisoeugenol in liver microsomes of human, rat, and bovine origin

AT Cartus, KH Merz, D Schrenk

文献索引：Cartus, Alexander T.; Merz, Karl-Heinz; Schrenk, Dieter Drug Metabolism and Disposition, 2011 , vol. 39, # 9 p. 1727 - 1733

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被引用次数: 11

摘要

Abstract Methylisoeugenol (1, 2-dimethoxy-4-propenylbenzene, 1) is a minor constituent of essential oils, naturally occurring as a mixture of cis/trans isomers. 1 is a US Food and Drug Administration-approved food additive and has been given “Generally Recognized as Safe” status. Previously, metabolism of 1 has been studied in the rat, revealing mainly nontoxic cinnamoyl derivatives as major metabolites. However, data concerning the possible ...