Anion??receptor molecules: Synthesis of a chiral and functionalized binding subunit, a bicyclic guanidinium group derived from L??or D??asparagine

A Echavarren, A Galán, J de Mendoza…

文献索引：Echavarren, Antonio; Galan, Amalia; Mendoza, Javier de; Salmeron, Armando; Lehn, Jean-Marie Helvetica Chimica Acta, 1988 , vol. 71, p. 685 - 693

全文：HTML全文

被引用次数: 80

摘要

Abstract The optically active (4S, 8S)-4, 8-bis (hydroxymethyl)-1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene ((S, S)-1) has been synthesized in nine steps from L-asparagine with a total yield of 5.1%. Similarly, the enantiomer (R, R)-1 has been prepared from D-asparagine.(S, S)-and (S, S)-1 are representative examples of rigid and functionalized bicyclic guanidine systems and constitute useful intermediates in the construction of chiral selective anion-receptor ...