The degradation of neohesperidin dihydrochalcone by human intestinal microbiota was studied in vitro. Human fecal slurries converted neohesperidin dihydrochalcone anoxically to 3-(3-hydroxy-4-methoxyphenyl) propionic acid or 3-(3, 4-dihydroxyphenyl) propionic acid. Two transient intermediates were identified as hesperetin dihydrochalcone 4'-β-d-glucoside and hesperetin dihydrochalcone. These metabolites suggest that neohesperidin ...
