Preliminary Pharmacological Evaluation of Enantiomeric Morphinans
AW Sromek, BA Provencher, S Russell…
文献索引：Sromek, Anna W.; Provencher, Brian A.; Russell, Shayla; Chartoff, Elena; Knapp, Brian I.; Bidlack, Jean M.; Neumeyer, John L. ACS Chemical Neuroscience, 2014 , vol. 5, # 2 p. 93 - 99
A series of levo-and dextromorphinan pairs have been synthesized and evaluated for their affinities to the mu, kappa, and delta opioid receptors, the N-methyl-d-aspartate (NMDA) channel, and sigma 1 and 2 receptors. It was found that levo isomers tended to have higher affinities at the opioid receptors and moderate to high affinities to the NMDA and sigma receptors, while dextro isomers tended to have lower affinities to the opioid receptors but ...
