Design, synthesis and biological activities of sorafenib derivatives as antitumor agents

J Yao, Z He, J Chen, W Sun, H Fang, W Xu

文献索引：Yao, Jianwen; He, Zuopeng; Chen, Jing; Sun, Wei; Fang, Hao; Xu, Wenfang Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6549 - 6553,5

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被引用次数: 4

摘要

A series of novel sorafenib derivatives, 9a–w, was designed and synthesized in high yields using various substituted anilines, and their antiproliferative activities against HCT116, PC-3 and MDA-MB-231 cell lines were also evaluated and described. All compounds exhibited potent antiproliferative activity against HCT116 and PC-3 cells with IC50= 2.8–52.0 and 2.2– 45.6 μM; compounds 9p and 9q demonstrated competitive antiproliferative activities to ...