Carboxyl-modified amino acids and peptides as protease inhibitors

SA Thompson, PR Andrews…

文献索引：Thompson, Stewart A.; Andrews, Peter R.; Hanzlik, Robert P. Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 104 - 111

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被引用次数: 96

摘要

Design Our purpose was to evaluate the inhibitory potential of functional groups incorporated into substrate analogues by testing them against proteases representing several different classes, while at the same time minimizing the amount of swthesis required. To meet this objective we selected five primary target enzymes which were commercially available and well characterized:(1) chymotrypsin (CT), a serine endoprotease preferring ...