Selective muscarinic antagonists. II. Synthesis and antimuscarinic properties of biphenylylcarbamate derivatives.

…, M HAYAKAWA, K IKEDA, T SHIBANUMA…

文献索引：Naito, Ryo; Takeuchi, Makoto; Morihira, Koichiro; Hayakawa, Masahiko; Ikeda, Ken; Shibanuma, Tadao; Isomura, Yasuo Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 8 p. 1286 - 1294

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被引用次数: 22

摘要

A novel series of biphenylylcarbamate derivaties were synthesized and evaluated for binding to M 1, M 2 and M 3 receptors and for antimuscarinic activities. Receptor binding assays indicated that biphenyl-2-ylcarbamate derivatives had high affinities for M 1 and M 3 receptors and good selectivities for M 3 receptor over M 2 receptor, indicating that the biphenyl-2-yl group is a novel hydrophobic replacement for the benzhydryl group in the ...