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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis and pharmacological study of prazosin

…, BA Medvedev, AA Kazakov, GP Zhikhareva…

文献索引：Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807

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被引用次数: 1

摘要

Synthesized in the course of broad scale studies in the search for quinazoline series~- adrenergic blockers [i, 9], Prazosin exhibits selective action on the postsynaptic~ 1- adrenergic receptors which accounts for its high level of gradually increasing and prolonged antihypertensive activity which is not attenuated upon repeated administration and which is not accompanied by reflex tachycardia. The strong peripheral vascular dilatation induced ...

7-氯喹唑啉-2,4-二酮结构式

7-氯喹唑啉-2,4-二酮

~99%

2,4,7-三氯喹唑啉结构式

2,4,7-三氯喹唑啉

2,7-dichloro-6,8-dinitroquinazolin-4-amine结构式

2,7-dichloro-6,...

1-(2-糠酰)哌嗪结构式

1-(2-糠酰)哌嗪

~58%

1-(4-Amino-7-chloro-6,8-dinitro-2-quinazolinyl)-4-(2-furanylcarbonyl)p iperazine HCl结构式

1-(4-Amino-7-ch...

7-氯喹唑啉-2,4-二酮结构式

7-氯喹唑啉-2,4-二酮

~%

1-(4-Amino-7-chloro-6,8-dinitro-2-quinazolinyl)-4-(2-furanylcarbonyl)p iperazine HCl结构式

1-(4-Amino-7-ch...

2,4,7-trichloro-6,8-dinitroquinazoline结构式

2,4,7-trichloro...

~%

1-(4-Amino-7-chloro-6,8-dinitro-2-quinazolinyl)-4-(2-furanylcarbonyl)p iperazine HCl结构式

1-(4-Amino-7-ch...

7-Chloro-6,8-dinitroquinazolinedione-2,4结构式

7-Chloro-6,8-di...

~%

1-(4-Amino-7-chloro-6,8-dinitro-2-quinazolinyl)-4-(2-furanylcarbonyl)p iperazine HCl结构式

1-(4-Amino-7-ch...

2-氨基-4-氯苯甲酸结构式

2-氨基-4-氯苯甲酸

~%

1-(4-Amino-7-chloro-6,8-dinitro-2-quinazolinyl)-4-(2-furanylcarbonyl)p iperazine HCl结构式

1-(4-Amino-7-ch...

2,4,7-三氯喹唑啉结构式

2,4,7-三氯喹唑啉

~90%

2,7-Dichloroquinazolin-4-amine结构式

2,7-Dichloroqui...

7-氯喹唑啉-2,4-二酮结构式

7-氯喹唑啉-2,4-二酮

~%

2,7-Dichloroquinazolin-4-amine结构式

2,7-Dichloroqui...

2-氨基-4-氯苯甲酸结构式

2-氨基-4-氯苯甲酸

~%

2,7-Dichloroquinazolin-4-amine结构式

2,7-Dichloroqui...

(2-phenyl-3-propan-2-yl-1,3-oxazolidin-5-yl)methanol结构式

(2-phenyl-3-pro...

2,4-二氯-6,7-二甲氧基喹唑啉结构式

2,4-二氯-6,7-二甲氧基喹唑啉

~91%

1-((2-Chloro-6,7-dimethoxy-4-quinazolinyl)oxy)-3-((1-methylethyl)amino )-2-propanol结构式

1-((2-Chloro-6,...

6,8-dibromo-2-chloroquinazolin-4-amine结构式

6,8-dibromo-2-c...

1-(2-糠酰)哌嗪结构式

1-(2-糠酰)哌嗪

~54%

1-(4-Amino-6,8-dibromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride结构式

1-(4-Amino-6,8-...

2-氨基-3,5-二溴苯甲酸结构式

2-氨基-3,5-二溴苯甲酸

~%

1-(4-Amino-6,8-dibromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride结构式

1-(4-Amino-6,8-...

6-溴-2-氯喹唑啉-4-胺结构式

6-溴-2-氯喹唑啉-4-胺

1-(2-糠酰)哌嗪结构式

1-(2-糠酰)哌嗪

~98%

1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hyd rochloride结构式

1-(4-Amino-6-br...

6-溴喹唑啉-2,4-二酮结构式

6-溴喹唑啉-2,4-二酮

~%

1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hyd rochloride结构式

1-(4-Amino-6-br...

6-溴-2,4-二氯喹唑啉结构式

6-溴-2,4-二氯喹唑啉

~%

1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hyd rochloride结构式

1-(4-Amino-6-br...

2-氨基-5-溴苯甲酸结构式

2-氨基-5-溴苯甲酸

~%

1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hyd rochloride结构式

1-(4-Amino-6-br...

2,7-Dichloroquinazolin-4-amine结构式

2,7-Dichloroqui...

1-(2-糠酰)哌嗪结构式

1-(2-糠酰)哌嗪

~66%

[4-(4-amino-7-chloroquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone结构式

[4-(4-amino-7-c...

2,4,7-三氯喹唑啉结构式

2,4,7-三氯喹唑啉

~%

[4-(4-amino-7-chloroquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone结构式

[4-(4-amino-7-c...

7-氯喹唑啉-2,4-二酮结构式

7-氯喹唑啉-2,4-二酮

~%

[4-(4-amino-7-chloroquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone结构式

[4-(4-amino-7-c...

2-氨基-4-氯苯甲酸结构式

2-氨基-4-氯苯甲酸

~%

[4-(4-amino-7-chloroquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone结构式

[4-(4-amino-7-c...

6-溴喹唑啉-2,4-二酮结构式

6-溴喹唑啉-2,4-二酮

~98%

6-溴-2,4-二氯喹唑啉结构式

6-溴-2,4-二氯喹唑啉