Phosphorus, Sulfur, and Silicon

Syntheses and Bioactivity of o-or p-Trifluoromethylphenyl Phosphates

X Zhou, Y He, M Wang, Y Ding

文献索引：Zhou, Xinming; He, Yantao; Wang, Miao; Ding, Yixiang Phosphorus, Sulfur and Silicon and the Related Elements, 2009 , vol. 184, # 3 p. 651 - 659

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被引用次数: 4

摘要

View all references Widlanski designed and synthesized 4-(fluoromethyl)phenyl phosphate, which is likely to function as a mechanism-based phosphotyrosine phosphatase inactivator. 4-(Fluoromethyl)phenyl phosphate undergoes a phosphatase-catalyzed hydrolytic reaction to give a reactive intermediate quinone methide that could irreversibly inactivate the phosphatase by forming a covalent bond to an active site residue (ie, OH, SH, and NH 2 groups) shown ...