Discussion Since a major portion of the work described here required flexibility in the choice of R, R1, and R'in structure 2, and thus 3 (see Tables IV), an important objective was to examine the scope of available isoindole syntheses in meeting this condition. Although a number of synthetic approaches to isoindoles have been described, few offer any degree of versatility for the substituents on the isoindole nucleus.'-'() Of these methods, only two, the ...
