Simple synthesis of carbon-11 labeled styryl dyes as new potential PET RNA-specific, living cell imaging probes

…, KD Miller, GW Sledge, GD Hutchins, QH Zheng

文献索引：Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; Zheng, Qi-Huang European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 2300 - 2306

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被引用次数: 28

摘要

A new type of styryl dyes have been developed as RNA-specific, live cell imaging probes for fluorescent microscopy technology to study nuclear structure and function. This study was designed to develop carbon-11 labeled styryl dyes as new probes for biomedical imaging technique positron emission tomography (PET) imaging of RNA in living cells. Precursors (E)-2-(2-(1-(triisopropylsilyl)-1H-indol-3-yl) vinyl) quinoline (2),(E)-2-(2, 4, 6- ...