Synthesis of high specific activity [1??14C] 3??N, N??dimethylaminopropylamine

Z Jian, C Filer, TP Kelly

文献索引：Jian, Zhigang; Filer, Crist; Kelly, Terence P. Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 8 p. 781 - 783

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摘要

Abstract A convenient synthesis of high specific activity [1-14 C] 3-N, N- dimethylaminopropylamine 10 is described. The reaction between [14 C] KCN and N, N- dimethyl bromoacetamide 7 afforded [nitrile-14 C] N, N-dimethyl cyanoacetamide 8. Stepwise reduction of 8 provided 99% pure 10 in 59% overall radiochemical yield. The specific activity was 53.3 mCi/mmol.© 1998 John Wiley & Sons, Ltd.