Tetrahedron letters

The synthesis of fragment a of an antibiotic, nosiheptide

…, H Noda, J Yoshimura, A Konn, Y Yonezawa, C Shin

文献索引：Umemura, Kazuyuki; Noda, Hirofumi; Yoshimura, Juji; Konn, Akihito; Yonezawa, Yasuchika; Shin, Chung-Gi Tetrahedron Letters, 1997 , vol. 38, # 20 p. 3539 - 3542

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被引用次数: 34

摘要

Fragment A derivative (13) of nosiheptide, useful for the total synthesis, was obtained by stepwise introduction of the 2, 5-bis {(4-ethoxycarbonyl)-2-thiazolyl} groups and 6-{(2- substituted)-4-thiazolyl} group into 3-hydroxy-5-cyanopyridine (3). The total yield was 7.6% via 14 steps.