Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics

N Charrier, B Clarke, L Cutler, E Demont…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 13 p. 3674 - 3678

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被引用次数: 41

摘要

... Bioorganic & Medicinal Chemistry Letters. ... The chemical space in which compounds with an acceptable lipophilicity profile (1 < Log D < 3) are predicted to be well absorbed is now populated, in contrast to the predictions for our first generation sultams. ...