Microbial transformation of cadina-4, 10 (15)-dien-3-one, aromadendr-1 (10)-en-9-one and methyl ursolate by Mucor plumbeus ATCC 4740
DO Collins, PLD Ruddock, JC de Grasse, WF Reynolds…
文献索引：Collins, Dwight O.; Ruddock, Peter L. D.; Grasse, Jessica Chiverton de; Reynolds, William F.; Reese, Paul B. Phytochemistry (Elsevier), 2002 , vol. 59, # 5 p. 479 - 488
The sesquiterpenes cadina-4, 10 (15)-dien-3-one (1) and aromadendr-1 (10)-en-9-one (squamulosone)(14) along with the triterpenoid methyl ursolate (21) were incubated with the fungus Mucor plumbeus ATCC 4740. Substrates 1, 14 and ursolic acid (20) were isolated from the plant Hyptis verticillata in large quantities. M. plumbeus hydroxylated 1 at C-12 and C-14. When the iron content of the medium was reduced, however, hydroxylation at these ...
