Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and Their kinetic studies with γ-Glutamyltranspeptidase

C Lherbet, M Morin, R Castonguay…

文献索引：Lherbet, Christian; Morin, Mylene; Castonguay, Roselyne; Keillor, Jeffrey W. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 997 - 1000

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被引用次数: 11

摘要

A new series of l-glutamic acid p-nitroanilide analogues has been synthesized and tested as substrates and inhibitors of rat kidney γ-glutamyltranspeptidase (GGT). Kinetic parameters (Km and kcat) were determined for each analogue and provide insight into the scope and limits of GGT catalytic efficiency.