Synthesis, ocular effects, and nitric oxide donation of imidazole amidoximes

…, O Oksala, E Pohjala, H Vapaatalo, E Moilanen…

文献索引：Oresmaa; Kotikoski; Haukka; Oksala; Pohjala; Vapaatalo; Moilanen; Vainiotalo; Aulaskari European Journal of Medicinal Chemistry, 2006 , vol. 41, # 9 p. 1073 - 1079

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被引用次数: 6

摘要

Novel 1-R-imidazole-5-amidoximes and 1-R-5-cyano-imidazole-4-amidoximes (R: H, Me, Bn) were prepared from their corresponding nitriles and were tested for their efficacy to lower intraocular pressure (IOP) in rabbits. The ability of these compounds to donate nitric oxide (NO) was studied by observing the stimulation of formation of cyclic guanosine-3′, 5′-monophosphate (cGMP) in the incubation of porcine iris-ciliary body. In the incubation ...