An Improved Process for the Synthesis of 5-Bromo-3-(1-methylpiperidin-4-yl)-1 H-indole: A Key Intermediate in the Synthesis of Naratriptan Hydrochloride
…, K Shridhara, HSB Naik, K Nagarajan
文献索引：Shashikumar, Nellisara D.; Krishnamurthy, Ganga Naika; Rao K, Sundara Raj; Shridhara, Kanakamajalu; Naik, Halehatti S. Bhojya; Nagarajan, Kuppuswamy Organic Process Research and Development, 2010 , vol. 14, # 4 p. 918 - 920
An improved process has been developed for the synthesis of 5-bromo-3-(1-methylpiperidin- 4-yl)-1 H-indole, a key intermediate of naratriptan hydrochloride, which is used as a drug for migraine. A novel one-pot synthetic procedure using triethyl silane was developed for scale- up.
