Tetrahedron letters

One-pot synthesis of L-felinine

DL Daniels, C Richert

文献索引：Daniels, Dwayne L.; Richert, Clemens Tetrahedron Letters, 1999 , vol. 40, # 24 p. 4463 - 4465

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被引用次数: 4

摘要

Conjugate addition of Boc-L-Cys-OH to 3-methylcrotonaldehyde, in situ reduction with sodium borohydride, and in situ deprotection with hydrochloric acid, directly followed by chromatography gives L-felinine in 73% yield. Similar syntheses may produce acid building blocks for combinatorial libraries.