[4-(Phenoxy) pyridin-3-yl] methylamines: A new class of selective noradrenaline reuptake inhibitors

PV Fish, T Ryckmans, A Stobie, F Wakenhut

文献索引：Fish, Paul V.; Ryckmans, Thomas; Stobie, Alan; Wakenhut, Florian Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 6 p. 1795 - 1798

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被引用次数: 9

摘要

[4-(Phenoxy) pyridine-3-yl] methylamines are disclosed as a new series of selective noradrenaline reuptake inhibitors (NRI). Structure–activity relationships established that potent NRI activity could be achieved by appropriate substitution at the 2-position of the phenoxy ring. Compound 31 demonstrated potent NRI activity combined with good selectivity over serotonin and dopamine reuptake and no significant off-target ...