Synthesis and SAR development of novel P2X 7 receptor antagonists for the treatment of pain: Part 1

JJ Matasi, S Brumfield, D Tulshian, M Czarnecki…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 12 p. 3805 - 3808

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被引用次数: 12

摘要

... Bioorganic & Medicinal Chemistry Letters. ... was a suitable replacement for the spiroindane system of lead 1. It was also established that C-2 benzyl group could be replaced with 4-flurophenyl with similar potency as 1. Hence, majority of SAR reported in this Letter was carried ...