4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

J Liddle, P Bamborough, MD Barker, S Campos…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 16 p. 5222 - 5226

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被引用次数: 9

摘要

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. ... Both 15 and 16 had a low volume of distribution (0.8 and 0.6 L/Kg, respectively) leading to a short half life of less than one hour. ...