Development of a Potent and Selective HDAC8 Inhibitor

OJ Ingham, RM Paranal, WB Smith…

文献索引：Liang, Xiaofei; Lee, Chul-Jin; Zhao, Jinshi; Toone, Eric J.; Zhou, Pei Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6954 - 6966

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摘要

... Select a Journal or Book. ... Dana Farber Cancer Institute, Boston, Massachusetts 02215, United States. § Department of Medicine, Harvard Medical School, Boston ... Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of ...