Synthesis and SAR of 1, 9-dihydro-9-hydroxypyrazolo [3, 4-b] quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors

M Liu, Z Xin, JE Clampit, S Wang, RJ Gum…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 10 p. 2590 - 2594

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被引用次数: 26

摘要

... Bioorganic & Medicinal Chemistry Letters. ... The novelty of the core structure 8 as well as its good selectivity profile motivated us to initiate hit to lead chemistry to explore the activity of this class of compounds as JNK1 inhibitors. ...