Abstract Analogs of the antiviral 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl) adenine (HPMPA, I), containing modified heterocyclic base, were prepared from racemic or (S)-N-(2, 3-dihydroxypropyl) derivatives II. Compounds II are heated with chloromethylphosphonyl dichloride (XVII), the formed chloromethylphosphonylester chlorides of compounds II react with water to give a mixture of 2'-and 3'-chloromethylphosphonyl derivatives XVIII and XIX, ...
