Synthesis of Regioselectively Functionalized Benzo [b] thiophenes by Combined ortho-Lithiation− Halocyclization Strategies

R Sanz, V Guilarte, E Hernando…

文献索引：Sanz, Roberto; Guilarte, Veronica; Garcia, Nuria Organic and Biomolecular Chemistry, 2010 , vol. 8, # 17 p. 3860 - 3864

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被引用次数: 37

摘要

An efficient synthesis of 3-halo-7-oxygen-functionalized benzo [b] thiophenes bearing different substituents at C-2 has been developed from N, N-diethyl O-3- halophenylcarbamates. The key steps are an ortho-lithiation reaction, which gives rise to 3-