Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties

…, SP Treanor, J Plowman, MA Priest…

文献索引：Marquez, Victor E.; Lim, Mu-Ill; Treanor, Susan P.; Plowman, Jacqueline; Priest, Matthew A.; et al. Journal of Medicinal Chemistry, 1988 ,  vol. 31,  # 9  p. 1687 - 1694

全文：HTML全文

被引用次数: 79

摘要

Cyclopentenylcytosine (CPEC, 2), a pyrimidine analogue of the fermentation derived carbocyclic nucleoside neplanocin A, has been synthesized from the optically active cyclopentenylamine 3b by two synthetic routes. CPE-C demonstrates signifiant antitumor activity against both the sensitive and ara-C resistant lines of L1210 leukemia in vivo. Multiple long term survivors are produced in both tumor models. The compound also gives ...