The Journal of Organic Chemistry

Stereospecific synthesis of ether and thioether phospholipids. The use of L-glyceric acid as a chiral phospholipid precursor

SK Bhatia, J Hajdu

文献索引：Bhatia, Suresh K.; Hajdu, Joseph Journal of Organic Chemistry, 1988 ,  vol. 53,  # 21  p. 5034 - 5039

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被引用次数: 33

摘要

A novel stereospecific synthesis of biologically active ether phospholipids is reported. The synthesis is based on (1) the use of L-glyceric acid as the chiral center for the construction of the optically active phospholipid molecule,(2) the introduction of the"-short chain alkyl substituent via silver tetrafluoroborate catalyzed alkylation reaction that leaves the neighboring carbomethoxy group unaffected, and then elaboration of the lipophilic alkoxy ...