Synthesis and antinociceptive properties of new structurally planned imidazo [1, 2-a] pyridine 3-acylarylhydrazone derivatives

…, KCM da Silva, SC Parrini, ALP de Miranda…

文献索引：Ribeiro, Izabella G.; Da Silva, Kelly Christine M.; Parrini, Sergio C.; De Miranda, Ana Luisa P.; Fraga, Carlos A. M.; Barreiro, Eliezer J. European Journal of Medicinal Chemistry, 1998 , vol. 33, # 3 p. 225 - 235

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被引用次数: 55

摘要

This paper describes recent results of a research program aiming at the synthesis and pharmacological evaluation of new N-heterocyclic functionalized acylarylhydrazone compounds, belonging to 3-acyl-(2-methyl-imidazo [1, 2-a] pyridinyl)-arylhydrazone 2 series. These compounds were structurally planned applying classical ring bioisosterism strategies on previously described 4-acyl-(N-phenylpyrazolyl)-arylhydrazone 1, which presented ...