Synthesis of Possible Cancer Chemotherapeutic Compounds Based on Enzyme Approach. I. Hemisulfur Mustard and Its Esters1

KC Tsou, HCF SU, C Segebarth…

文献索引：Tsou,K.C. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 4987 - 4990

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被引用次数: 14

摘要

Hemisulfur mustard, Zchloro-2'-hydroxydiethyl sulfide (I), has been prepared from sodiomercaptoethanol and ethylene chloride, The stability of I is measured by the use of P (p- nitrobenzy1) pyridine (NBP). Direct acylation of I with acid chlorides yields ita corresponding esters. Alternatively, these esters may be prepared by first addition of mercaptoethanol to vinyl esters or direct monoacylation of thiodiglycol, followed by chlorination of the ...