Towards a robust and reliable method for the reduction of functionalized sulfoxides

J Ternois, F Guillen, G Piacenza, S Rose…

文献索引：Ternois, James; Guillen, Frederic; Piacenza, Guy; Rose, Sebastien; Plaquevent, Jean-Christophe; Coquerel, Gerard Organic Process Research and Development, 2008 , vol. 12, # 4 p. 614 - 617

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被引用次数: 3

摘要

As part of our ongoing studies on the synthesis (R)-modafinil and its derivatives, we previously described both resolution(3) and enantioselective methods.(4) (R)-Modafinil can be obtained by resolution using either chiral chromatography or preferential crystallization of its precursor, (RS)-modafinic acid.(3, 5) However, such nondynamic resolution procedures suffer from a major drawback with respect to enantioselective syntheses, ie the inherent ...