Tetrahedron: Asymmetry

Asymmetric synthesis of ACE inhibitor-Benazepril HCl via a bioreductive reaction

CY Chang, TK Yang

文献索引：Chang, Ching-Yao; Yang, Teng-Kuei Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2239 - 2245

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被引用次数: 29

摘要

An enantioselective synthesis of the potent angiotensin converting enzyme (ACE) inhibitor (2S, 3′ S)-2-(1-carboxymethyl-2-oxo-2, 3, 4, 5-tetrahydro-1H-benzo [b] azepin-3-ylamino)-4- phenylbutyric acid ethyl ester hydrochloride, Benazepril HCl 4, has been achieved through an asymmetric reduction of 4-(2-nitrophenyl)-2, 4-dioxobutyric acid ethyl ester 6b employing baker's yeast as the reductive catalyst.